ICOSLG polyclonal Antibody | BS8696

ICOSLG polyclonal Antibody | BS8696 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200

Background: T cell costimulatory molecule, inducible costimulator (ICOS) /B7-related protein-1 (B7RP-1, B7-H2, GL50, ICOS-L) is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. B7RP-1 interactions play an essential role in T cell dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. B7RP-1 protein is present in myeloid leukocytes and by Northern blot there are 2.4, 3.0 and 7.0 kb transcripts in brain, heart, kidney and liver, with lower expression in colon and thymus and a 1.1 kb transcript in leukocytes. Tumor necrosis factor å (TNFå), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4) enhance B7RP-1 expression. LPS induced up regulation of B7RP-1 is dependent on the MyD88 dependent signaling pathway.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ICOSLG polyclonal Antibody detects endogenous levels of ICOSLG protein.

Molecular Weight: ~ 50-70kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ICOS ligand; B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD275; ICOSLG; B7H2, B7RP1, ICOSL, KIAA0653

Immunogen: Recombinant full length Human ICOSLG.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: