iCRT14 | B2562

iCRT14 is a potent potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling in a reporter assay in vitro (IC₅₀ = 40.3 nM). It inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) in quantitative reporter assays of β-catenin/Tcf4 binding (Ki = 53.51 μM). It inhibits Notch, hedgehog (Hh), and JAK/STAT signaling in reporter assays with IC50 values of 69.2, 194, and 70 nM, respectively.

iCRT14 is a potent potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling in a reporter assay in vitro (IC₅₀ = 40.3 nM). It inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) in quantitative reporter assays of β-catenin/Tcf4 binding (Ki = 53.51 μM). It inhibits Notch, hedgehog (Hh), and JAK/STAT signaling in reporter assays with IC50 values of 69.2, 194, and 70 nM, respectively.

B2562 | iCRT14 DataSheet

Alternate Name/Synonyms: iCRT 14, Wnt inhibitor, 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione, iCRT-14

Appearance: Crystalline solid

Formulation:

CAS Number: 677331-12-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₇N₃O₂S

Molecular Weight: 375.45

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: ~2 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A Wnt inhibitor

MDL Number:

PubChem CID:

SMILES: O=C(S/C1=C\C2=C(C)N(C3=CN=CC=C3)C(C)=C2)N(C4=CC=CC=C4)C1=O

InChi: InChI=1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-

InChi Key: NCSHZXNGQYSKLR-UNOMPAQXSA-N