IDO2 Polyclonal Antibody | E-AB-18375

IDO2 Polyclonal Antibody | E-AB-18375 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: 3-dioxygenase 2, 3-dioxygenase-like protein 1, EC 1.13.11., I23O2, IDO 2, IDO-2, Ido2, INDOL 1, Indoleamine 2, Indoleamine 2, 3 dioxygenase 2, Indoleamine 2, 3 dioxygenase like 1 protein, Indoleamine 2, 3 dioxygenase like protein 1, Indoleamine pyrrole 2, 3 dioxygenase like 1, Indoleamine pyrrole 2, 3 dioxygenase like protein 1, Indoleamine-pyrrole 2

Application: WB, IHC, ELISA

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Metabolism, Signal Transduction

Background: INDOL1 is also known as IDO2 (indoleamine 2, 3-dioxygenase 2) and is a 407 amino acid protein that is expressed in various tissues, including liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, colon and dendritic cells. INDOL1 is selectively inhibited by D-1MT (1-methyl-d-tryptophan), which also inhibits IDO (indoleamine 2, 3-dioxygenase) and is significant because IDO expression causes suppression of T cell responses to tumors in dendritic cells. The inhibition of INDOL1 by D-1MT suggests a common function in immunomodulation. In the human INDOL1 gene, two single nucleotide polymorphisms have been detected which abolish the enzymatic function of INDOL1.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Full length fusion protein

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 45 kDa

Molecular Weight(Observed): Refer to figures