IFIT3 Antibody | 7759

IFIT3 Antibody | 7759 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: IFIT3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human IFIT3.
The immunogen is located within amino acids 380 - 430 of IFIT3 .

Research Area: Innate Immunity

Tested Application: E, WB, IHC-P

Application: IFIT3 antibody can be used for detection of IFIT3 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Specificiy: IFIT3 antibody is human specific. This antibody is predicted to not cross-react with other members of the IFIT protein family.

Positive Control 1: Cat. No. 1211 - HepG2 Cell Lysate

Positive Control 2: Cat. No. 10-201 - Human Liver Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 54 kDa
Observed: 50 kDa

Validation: N/A

Isoform: N/A

Purification: IFIT3 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: IFIT3 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: IFIT3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: IFIT3 Antibody : P60, IRG2, IFI60, IFIT4, ISG60, RIG-G, CIG-49, GARG-49, Interferon-induced protein with tetratricopeptide repeats 3, CIG49, IFIT-3

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) protein is a member of a family of tetratricopeptide repeat-containing proteins whose transcription is upregulated by interferons, virus infection, and molecular patterns such as dsRNA or lipopolysaccharides (1, 2) . These proteins have been suggested to induce anti-viral cellular activities in response to infection (2) . IFIT3 has been shown to interact with TBK1 following RNA virus infection, thereby bridging TBK1 to VISA on the mitochondrion and activating IRF3 and thus the immune response (3) .