Description
IFIT3 Antibody | 7759 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human
Homology: N/A
Immunogen: IFIT3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human IFIT3.
The immunogen is located within amino acids 380 - 430 of IFIT3 .
Research Area: Innate Immunity
Tested Application: E, WB, IHC-P
Application: IFIT3 antibody can be used for detection of IFIT3 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Specificiy: IFIT3 antibody is human specific. This antibody is predicted to not cross-react with other members of the IFIT protein family.
Positive Control 1: Cat. No. 1211 - HepG2 Cell Lysate
Positive Control 2: Cat. No. 10-201 - Human Liver Tissue Slide
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Predicted: 54 kDa
Observed: 50 kDa
Validation: N/A
Isoform: N/A
Purification: IFIT3 antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: IFIT3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: IFIT3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Alternate Name: IFIT3 Antibody : P60, IRG2, IFI60, IFIT4, ISG60, RIG-G, CIG-49, GARG-49, Interferon-induced protein with tetratricopeptide repeats 3, CIG49, IFIT-3
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) protein is a member of a family of tetratricopeptide repeat-containing proteins whose transcription is upregulated by interferons, virus infection, and molecular patterns such as dsRNA or lipopolysaccharides (1, 2) . These proteins have been suggested to induce anti-viral cellular activities in response to infection (2) . IFIT3 has been shown to interact with TBK1 following RNA virus infection, thereby bridging TBK1 to VISA on the mitochondrion and activating IRF3 and thus the immune response (3) .