BW
IGF-2R Rabbit monoclonal Antibody | BS9874M
- SKU:
- BW-BS9874M
- Availability:
- Usually ships in 5 working days
Description
IGF-2R Rabbit monoclonal Antibody | BS9874M | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB ICC/IF IHC FC
Application Range: WB: 1:1000-1:5000 ICC/IF: 1:50-1:200 IHC: 1:50-1:200 FC: 1:50-1:100
Background: The mannose 6-phosphate/insulin-like growth factor II receptor, IGF-IIR (also designated M6P/IGF2R), is an ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGFβ1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore,IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of IGF-2R and does not cross-react with related proteins.
Molecular Weight: ~ 274 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD222; MPRI; IGF2R
Immunogen: Recombinant Antibody.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein A affinity purified
Pathway: