IkB-α (Y42) polyclonal Antibody | AP0643

IkB-α (Y42) polyclonal Antibody | AP0643 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IP IF IHC

Application Range: WB: 1:1000~1:2000 IHC: 1:50~1:200 IF: 1:50~1:200

Background: The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins. Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB. IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IkB-α (T42)  polyclonal Antibody detects endogenous levels of IkB-α protein.

Molecular Weight: ~ 39 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha;IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3; NFKBIA; IKBA; MAD3; NFKBI

Immunogen: Synthetic peptide, corresponding to Human IkB-α.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Death Receptor Signaling,Inhibition of Apoptosis,NF-kB Signaling,T cell receptor signaling,