IL-11Rα (D361) polyclonal Antibody | BS9265

IL-11Rα (D361) polyclonal Antibody | BS9265 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: The pleiotropic cytokine, IL-11, has been shown to have proliferative and differentiation effects on lymphopoietic, myeloid and erythroid cells. IL-11 also has the inhibiting effect of repressing adipogenesis in vitro. The IL-11α receptor, IL-11Rα, is a member of the class 1 subgroup of the cytokine receptor family and exhibits structural similarity to the α subunits of the human ciliary neurotrophic factor (CNTF) and the mouse IL-6 receptor. It is speculated that the IL-11Rα regulates the proliferation and/or differentiation of skeletogenic progenitor and mesenchymal cells. Coexpression of gp130 and IL-11α is necessary for high-affinity binding of IL-11 to IL-11Rα. It has also been found that coexpression of IL-11Rα and gp130 is required for proper stimulation of Ba/F3 cells to differentiate into macrophage in response to IL-11.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IL-11Rα (D361) polyclonal Antibody detects endogenous levels of IL-11Rα protein.

Molecular Weight: ~ 45 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Interleukin-11 receptor subunit alpha; IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA; IL11RA

Immunogen: Synthetic peptide, corresponding to amino acids 330-380 of Human IL-11Rα.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: