IL-13, rat recombinant | 4166

IL-13 is an immunoregulatory cytokine produced mainly by T helper 2 cells, but also by mast cells and NK cells. IL-13 is a unique cytokine having similar structural features and functional characteristics as IL-4, but only shares ~30% homolog with the IL-4 sequence. IL-13 inhibits IL-1, IL-6, IL-8, and TNF- resulting in anti-inflammatory effects on monocytes and macrophages. IL-13 also induces B cells to proliferate and modulating TH2 cell development. Recombinant rat IL-13 is an 11.9 kDa protein containing 109 amino acid residues.

4166 | IL-13 rat recombinant DataSheet

Biomolecule/Target: IL-13

Synonyms: NC30, ALRH, BHR1, P600, IL-13, MGC116786, MGC116788, MGC116789.

Alternates names: Dihydrofolate reductase.

Taglines: A mediator of allergic inflammation and disease

NCBI Gene ID #: 1719

NCBI Gene Symbol: DHFR

Gene Source: Human

Accession #: P00374

Recombinant: Yes

Source: E. Coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: 95%

Assay #2: HPLC

Endotoxin Level: <0.1 ng/g

Activity (Specifications/test method): N/A

Biological activity: Specific activity is > 2000 pmol/min/ug, and is defined as the amount of enzyme that converts 1.0 pmole of dihydrofolic acid to tetrahydrofolic acid per minute at pH 6.5 at 25C.

Results: 1.5 - 2.5 units/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 23.6 kDa (207 aa, 1-187 aa + NT His-Tag)

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Sterile filtered and lyophilized with no additives

Reconstitution Instructions: N/A

Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MVGSLNCIVA VSQNMGIGKN GDLPWPPLRN EFRYFQRMTT TSSVEGKQNL VIMGKKTWFS IPEKNRPLKG RINLVLSREL KEPPQGAHFL SRSLDDALKL TEQPELANKV DMVWIVGGSS VYKEAMNHPG HLKLFVTRIM QDFESDTFFP EIDLEKYKLL PEYPGVLSDV QEEKGIKYKF EVYEKND