IL-17RA Antibody | 7419

IL-17RA Antibody | 7419 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: IL-17RA antibody was raised against an 18 amino acid peptide near the amino terminus of human IL-17RA.
The immunogen is located within amino acids 150 - 200 of IL-17RA.

Research Area: Immunology

Tested Application: E, WB, IHC-P, IF

Application: IL-17RA antibody can be used for detection of IL-17RA by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: IL-17RA antibody is human, mouse and rat reactive. Multiple isoforms of IL-17RA are known to exist. This antibody is predicted to not cross-react with other IL-17 receptor subunits.

Positive Control 1: Cat. No. 1288 - A20 Cell Lysate

Positive Control 2: Cat. No. 10-901 - Human Spleen Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 95 kDa
Observed: 135 kDa

Validation: N/A

Isoform: N/A

Purification: IL-17RA Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: IL-17RA Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: IL-17RA antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: IL-17RA Antibody: CD217, IL17R, CANDF5, CDw217, IL-17RA, hIL-17R, Interleukin-17 receptor A, IL-17 receptor A

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: IL-17RA Antibody: Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes (1) . It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F (1, 2) . IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis (3, 4) . Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections (5) .