IL-2 Receptor , Human Recombinant | 7100

The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2R, IL-2R, and IL-2R. The IL-2R is a type I transmembrane protein consisting of a 219 amino acid extracellular domain, a 19 amino acid transmembrane domain and a 13 amino acid intracellular domain, which is not involved in the transduction of IL-2 signals. Proteolytic processing of IL-2R releases the entire extracellular domain of IL-2R thereby generating a 219 amino acid soluble protein called soluble IL-2R (sIL-2R). The homodimeric form binds IL-2 (KD=10mM) and facilitates IL-2 signaling. The secreted sIL-2R is expressed on leukemia cells, lymphoma cells, newly activated T and B cells, as well as on approximately 10% of NK cells. Recombinant human sIL-2R is a 24.8 kDa protein containing 219 amino acid residues consisting of only the extracellular domain of IL-2R. Due to glycosylation, IL-2R has an approximate molecular weight of 31 kDa based on SDSPAGE Gel and Mass Spectrometry.

7100 | IL-2 Receptor Human Recombinant DataSheet

Biomolecule/Target: IL-2 R

Synonyms: soluble IL-2 receptor, TAC-antigen, CD25 antigen

Alternates names:

Taglines: A receptor present on immune cells like lymphocytes, which binds and responds to IL-2 cytokine

NCBI Gene ID #: 6233

NCBI Gene Symbol: RPS27A

Gene Source: Human

Accession #: P62979

Recombinant: Yes

Source: E. Coli

Purity by SDS-PAGEs: 95%

Assay: RP-HPLC

Purity: N/A

Assay #2: HPLC

Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 8.732 kDa

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized from 1x PBS

Reconstitution Instructions: N/A

Amino acid sequence: N/A