26
IL-2 Receptor , Human Recombinant | 7100
- SKU:
- 26-7100-GEN
- Availability:
- Usually shipped in 5 working days
Description
The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2R, IL-2R, and IL-2R. The IL-2R is a type I transmembrane protein consisting of a 219 amino acid extracellular domain, a 19 amino acid transmembrane domain and a 13 amino acid intracellular domain, which is not involved in the transduction of IL-2 signals. Proteolytic processing of IL-2R releases the entire extracellular domain of IL-2R thereby generating a 219 amino acid soluble protein called soluble IL-2R (sIL-2R). The homodimeric form binds IL-2 (KD=10mM) and facilitates IL-2 signaling. The secreted sIL-2R is expressed on leukemia cells, lymphoma cells, newly activated T and B cells, as well as on approximately 10% of NK cells. Recombinant human sIL-2R is a 24.8 kDa protein containing 219 amino acid residues consisting of only the extracellular domain of IL-2R. Due to glycosylation, IL-2R has an approximate molecular weight of 31 kDa based on SDSPAGE Gel and Mass Spectrometry.
7100 | IL-2 Receptor Human Recombinant DataSheet
Biomolecule/Target: IL-2 R
Synonyms: soluble IL-2 receptor, TAC-antigen, CD25 antigen
Alternates names:
Taglines: A receptor present on immune cells like lymphocytes, which binds and responds to IL-2 cytokine
NCBI Gene ID #: 6233
NCBI Gene Symbol: RPS27A
Gene Source: Human
Accession #: P62979
Recombinant: Yes
Source: E. Coli
Purity by SDS-PAGEs: 95%
Assay: RP-HPLC
Purity: N/A
Assay #2: HPLC
Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 8.732 kDa
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized from 1x PBS
Reconstitution Instructions: N/A
Amino acid sequence: N/A