IL-22 Antibody | 7593

IL-22 Antibody | 7593 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: IL-22 antibody was raised against a 17 amino acid peptide near the center of human IL-22 .
The immunogen is located within amino acids 90 - 140 of IL-22.

Research Area: Immunology

Tested Application: E, WB, ICC, IF

Application: IL-22 antibody can be used for detection of IL-22 by Western blot at 0.5 μg/ml. Antibody can also be used for Immunocytochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: IL-22 antibody is human, mouse, and rat reactive. Multiple isoforms of IL-22 are known to exist.

Positive Control 1: Cat. No. 1201 - HeLa Cell Lysate

Positive Control 2: Cat. No. 17-001 - HeLa Cell Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 20 kDa
Observed: 17 kDa

Validation: N/A

Isoform: N/A

Purification: IL-22 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: IL-22 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: IL-22 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: IL-22 Antibody: TIFa, IL-21, IL-22, ILTIF, IL-TIF, IL-D110, zcyto18, TIFIL-23, ZCYTO18, UNQ3099/PRO10096, Interleukin-22, Cytokine Zcyto18

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Interleukin-22 (IL-22) is a cytokine important for the modulation of tissue responses during inflammation (1) . Unlike the distantly related IL-10, IL-22 does not inhibit the production of proinflammatory cytokines in monocytes in response to LPS, but it has some inhibitory effects on IL-4 production from Th2 T cells. IL-22 is expressed by both the adaptive arm of the immune system such as CD4 T cell subsets including Th17 cells, as well as by innate lymphocytes such as NK and LTi-like cells (2) . IL-22 is highly expressed in several chronic inflammatory conditions, and studies suggest that IL-22 plays both inflammatory and protective roles (3) .