IL-36, Human Recombinant | 7111

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 (IL-1F6), (IL-1F8) and (IL-1F9). IL-36 is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36 signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36 also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant human IL-36 is a 17.0 kDa protein containing 152 amino acid residues.

7111 | IL-36 Human Recombinant DataSheet

Biomolecule/Target: IL-36

Synonyms: IL-1F, IL-1 (epsilon), IL-1F9, IL-1H1

Alternates names: UBE1, UBA1, POC20, A1S9T, A1ST, AMCX1, GXP1, SMAX2

Taglines: An agonist of NF-kappaB

NCBI Gene ID #: 7317

NCBI Gene Symbol: UBA1

Gene Source: Human

Accession #: P22314

Recombinant: Yes

Source: N/A

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).

Activity (Specifications/test method): N/A

Biological activity: Typical enzyme concentration of 5 nM – 100 nM is used for in vitro conjugation, depending on conditions.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 118 kDa

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 7.0 and 50 mM NaCl.

Reconstitution Instructions: N/A

Amino acid sequence: N/A