IL-36RN Antibody | 7511

IL-36RN Antibody | 7511 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: IL-36RN antibody was raised against a 19 amino acid peptide near the carboxy terminus of human IL-36RN.
The immunogen is located within the last 50 amino acids of IL-36RN.

Research Area: Immunology

Tested Application: E, WB, IHC-P, IF

Application: IL-36RN antibody can be used for detection of IL-36RN by Western blot at 1 μg/ml.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Specificiy: IL-36RN antibody is human and mouse reactive. At least two isoforms of IL-36RN are known to exist

Positive Control 1: Cat. No. 1306 - Human Spleen Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed Molecular Weight: 24 kDa

Validation: N/A

Isoform: N/A

Purification: IL-36RN antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: IL-36RN antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: IL-36RN antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: IL-36RN Antibody: FIL1, FIL1D, IL1F5, IL1L1, PSORP, IL1HY1, IL1RP3, IL36RA, FIL1 (DELTA) , UNQ1896/PRO4342, Interleukin-36 receptor antagonist protein, FIL1 delta, IL-1RP3

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: IL-36RN is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1) . IL-36RN specifically inhibits the activation of NF-kappaB induced IL-36A (2) . The opposing activities of these cytokines have been suggested to be involved in the regulation of skin inflammation (3) . Like the IL-36 cytokines (IL-36A, IL-36B and IL-36G) , IL-36RN requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (4) .