IL-37 Antibody | 7499

IL-37 Antibody | 7499 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: IL-37 antibody was raised against a 17 amino acid peptide near the amino terminus of human IL-37.
The immunogen is located within amino acids 30 - 80 of IL-37 .

Research Area: Immunology

Tested Application: E, WB, IHC-P, IF

Application: IL-37 antibody can be used for detection of IL-37 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: IL-37 antibody is human specific. Multiple isoforms of IL-37 are known to exist; this antibody will only detect the largest isoform. IL-37 antibody is predicted to not cross-react with IL-36.

Positive Control 1: Cat. No. 1302 - Human Lung Tissue Lysate

Positive Control 2: Cat. No. 10-401 - Human Kidney Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 24 kDa
Observed: 23kDa

Validation: N/A

Isoform: N/A

Purification: IL-37 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: IL-37 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: IL-37 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: IL-37 Antibody : FIL1, FIL1Z, IL-1H, IL-37, IL1F7, IL1H4, IL-1F7, IL-1H4, IL1RP1, IL-1RP1, FIL1 (ZETA) , Interleukin-37, FIL1 zeta

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Interleukin 37 (IL-37) is a member of the interleukin 1 cytokine family (reviewed in 1) . It can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp) . IL-37 also binds to interleukin 18 binding protein (IL18BP) , an inhibitory binding protein of interleukin 18 (IL18) , and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18 (1) . IL-37 can also interact with Smad3 and expression of IL-37 in macrophages or epithelial cells resulted in near complete suppression of pro-inflammatory cytokines, suggesting that IL-37 may act as a natural suppressor of the innate inflammatory and immune responses (2, 3) .