IL-4, murine recombinant | 4138

IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant murine IL-4 is a 13.5 kDa globular protein containing 120 amino acid residues.

4138 | IL-4 murine recombinant DataSheet

Biomolecule/Target: IL-4

Synonyms: BCGF,BCDF, B cell stimulating factor, BSF-1,Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra,

Alternates names: Ubiquitin-conjugating enzyme E2 L3, EC 6.3.2.19, Ubiquitin-protein ligase L3, Ubiquitin carrier protein L3, UbcH7, E2-F1, L-UBC, UbcM4.

Taglines: A key regulator in humoral and adaptive immunity

NCBI Gene ID #: 7332

NCBI Gene Symbol: UBE2L3

Gene Source: Human

Accession #: P68036

Recombinant: Yes

Source: N/A

Purity by SDS-PAGEs: 95%

Assay: RP-HPLC

Purity: 98%

Assay #2: HPLC

Endotoxin Level: <0.1 ng/g

Activity (Specifications/test method): N/A

Biological activity: Typical enzyme concentration of 100 nM - 1 mM is used for in vitro conjugation, depending on conditions.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 17.861 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized with no additives.

Reconstitution Instructions: N/A

Amino acid sequence: N/A