IL11RA Antibody (C-Term) [ApR04902G]

IL11RA Antibody (C-Term) [ApR04902G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This IL11RA antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 372-403 amino acids from human IL11RA.

Cellular Localisation: [Interleukin-11 receptor subunit alpha]: Membrane; Single-pass type I membrane protein [Isoform HCR2]: Secreted

Molecular Weight: 45222

Clone: Polyclonal

Gene Name: IL11RA (HGNC:5967)

Gene ID: 3590

Function: Receptor for interleukin-11 (IL11) . The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable) . Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.

Summary: Tissue Location: Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2 (PubMed:7670098) . Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Interleukin-11 receptor subunit alpha, IL-11 receptor subunit alpha, IL-11R subunit alpha, IL-11R-alpha, IL-11RA, IL11RA