IL12RB1 Polyclonal Antibody | E-AB-66049

IL12RB1 Polyclonal Antibody | E-AB-66049 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: IL12RB1, CD212, IL-12R-BETA1, IL12RB, IMD30

Application: IHC, IF

Reactivity: Human, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Immunology

Background: The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant fusion protein of human IL12RB1 (NP_714912.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: IHC 1:50-1:200 IF 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A