IL13RA2 polyclonal Antibody | BS8066

IL13RA2 polyclonal Antibody | BS8066 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB,IHC

Application Range: WB 1:2000 - 1:5000 IHC 1:50 - 1:200

Background: The Th2 cytokine Interleukin-13 (IL-13) plays a critical role in allergen-induced airway hyper-responsiveness (AHR) . Two different receptors exist for IL-13, designated IL-13Rα1 and 2. IL-13Rα1 exists as a heterodimer of IL-13Rα1 and IL-4Rα as a signaling subunit, whereas IL-13Rα2 acts as a decoy receptor for IL-13. Furthermore, TNFα or IL-4 stimulation induces IL-13Rα2 upregulation, while IL-13Rα1 is constitutively expressed. Cell surface localization of IL-13Rα2 abrogates IL-13 signaling, thus IL-13 induced translocation of the receptor from the cytoplasm provides a mechanism for negative-feedback of IL-13 signaling. IL-13Rα1 expression is predominant in B cells, monocytes and T cells, whereas IL-13Rα2 expression is highest in glioma cells.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IL13RA2 polyclonal Antibody detects endogenous levels of IL13RA2 protein.

Molecular Weight: ~ 44 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Interleukin-13 receptor subunit alpha-2; IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2; Interleukin-13-binding protein; CD213a2; IL13RA2; IL13R

Immunogen: Recombinant full length Human IL13RA2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: