IL17 A/F, Mouse Recombinant | 7586

Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17R receptor, its biological function is similar to that of IL-17A in that it induces the production of a variety of chemokines, in addition to airway neutrophilia. In regard to these functions, IL-17AF has less activity than the IL-17A homodimer but, greater activity than the IL-17F homodimer. Human and rat IL-17AF both show activity on mouse cells. Recombinant mouse IL-17AF is a non-glycosylated, disulfide-linked heterodimer. It is comprised of one monomeric subunit each of IL-17A and IL-17F, having a total of 271 amino acids and a molecular weight of 30.7 kDa.

7586 | IL17 A/F Mouse Recombinant DataSheet

Biomolecule/Target: IL17 A/F

Synonyms: Interleukin 17 A/F, IL-17A, IL-17F, Interleukin 17A, Interleukin 17F

Alternates names: Sorbitol dehydrogenase

Taglines: Induces the production of a variety of chemokines

NCBI Gene ID #: 6652

NCBI Gene Symbol: SORD

Gene Source: Human

Accession #: Q00796

Recombinant: Yes

Source: E. Coli

Purity by SDS-PAGEs: 90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Measured by kinetic LAL analysis and is typically 1 EU/g protein

Activity (Specifications/test method): N/A

Biological activity: Specific activity is > 0.2 units/mg

Results: >0.2 units/mg

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 40.4 kDa (377 aa, 1-357 aa + NT His Tag)

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized without any additives.

Reconstitution Instructions: N/A

Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MAAAAKPNNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH YWEYGRIGNF IVKKPMVLGH EASGTVEKVG SSVKHLKPGD RVAIEPGAPR ENDEFCKMGR YNLSPSIFFC ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE EGALIEPLSV GIHACRRGGV TLGHKVLVCG AGPIGMVTLL VAKAMGAAQV VVTDLSATRL SKAKEIGADL VLQISKESPQ EIARKVEGQL GCKPEVTIEC TGAEASIQAG IYATRSGGTL VLVGLGSEMT TVPLLHAAIR EVDIKGVFRY CNTWPVAISM LASKSVNVKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC DPSDQNP