IL17RE Antibody (N-term) [APR04458G]

IL17RE Antibody (N-term) [APR04458G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This IL17RE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the N-terminal region of human IL17RE.

Cellular Localisation: [Isoform 1]: Cell membrane; Single- pass type I membrane protein [Isoform 3]: Secreted. [Isoform 5]: Secreted.

Molecular Weight: 74810

Clone: Polyclonal

Gene Name: IL17RE

Gene ID: 132014

Function: Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.

Summary: Tissue Location: Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Interleukin-17 receptor E, IL-17 receptor E, IL-17RE, IL17RE