IL18BP, human recombinant | 7324

IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Recombinant human IL18BP protein, fused to His-tag at N-terminus, was expressed in E.coli.

7324 | IL18BP human recombinant DataSheet

Biomolecule/Target: IL18BP

Synonyms: Interleukin-18-binding protein, IL18BPa

Alternates names: Interleukin-18-binding protein, IL18BPa

Taglines: An inhibitor of the proinflammatory cytokine, IL18

NCBI Gene ID #: 15945

NCBI Gene Symbol: IP10

Gene Source: Human

Accession #: P17515

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 97%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per 1 microgram of protein

Activity (Specifications/test method): N/A

Biological activity: The biological activity of murine IP-10 was determined by its ability to chemoattract IL-2 activated T cells using a concentration range of 0.1-10 ng /ml.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 20 kDa (187 aa, 31-194 aa + His Tag), confirmed by MALDI-TOF.

Concentration: 1 mg/ml

Appearance: Liquid

Physical form description: 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.

Reconstitution Instructions: N/A

Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MGSTPVSQTT TAATASVRST KDPCPSQPPV FPAAKQCPAL EVTWPEVEVP LNGTLSLSCV ACSRFPNFSI LYWLGNGSFI EHLPGRLWEG STSRERGSTG TQLCKALVLE QLTPALHSTN FSCVLVDPEQ VVQRHVVLAQ LWAGLRATLP PTQEALPSSH SSPQQQG