ILK polyclonal Antibody | BS90712

ILK polyclonal Antibody | BS90712 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC IHC IP FC

Application Range: WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: Integrins are heterodimers composed of non-covalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind to ligands that are components of the extracellular matrix. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. ILK (integrin-linked kinase) was identified as a serine/threonine kinase that phosphorylates b1 and b3 integrins. ILK expression has been shown to be reduced in response to Fibronectin, a known integrin ligand. Overexpression of ILK was shown to upregulate the Fibronectin matrix assembly in epithelial cells, indicating a potential role for ILK in cell growth, cell survival and tumorigenesis.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: ILK polyclonal Antibody detects endogenous levels of ILK protein.

Molecular Weight: 51 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ILK, 59 kDa serine/threonine protein kinase, 59 kDa serine/threonine-protein kinase, DKFZp686F1765, Epididymis secretory protein Li 28, HEL S 28, ILK 1, ILK 2, ILK, ILK-1, ILK-2, ILK, ILK1, ILK2, Integrin linked kinase 2, Integrin linked Kinase, Integrin linked protein kinase, Integrin-linked protein kinase, p59, p59ILK,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: