IM-12 | 2822

IM-12 is a potent and selective GSK-3β inhibitor (IC₅₀ = 53 nM). It significantly increases β-catenin levels, leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells via activation of canonical Wnt signaling.

IM-12 is a potent and selective GSK-3β inhibitor (IC₅₀ = 53 nM). It significantly increases β-catenin levels, leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells via activation of canonical Wnt signaling.

2822 | IM-12 DataSheet

Alternate Name/Synonyms: 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Appearance: Yellow orange solid

Formulation: N/A

CAS Number: 1129669-05-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₀FN₃O₂

Molecular Weight: 377.41

Cell-Permeable?: yes

Purity: ≥98% by HPLC

Solubilities: DMSO (25 mg/ml) or EtOH (5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective GSK-3β inhibitor

MDL Number: MFCD20527313

PubChem CID: 25209788

SMILES: CC1=C(C2=CC=CC=C2N1)C3=C(C(=O)N(C3=O)C)NCCC4=CC=C(C=C4)F

InChi: InChI=1S/C22H20FN3O2/c1-13-18(16-5-3-4-6-17(16)25-13)19-20(22(28)26(2)21(19)27)24-12-11-14-7-9-15(23)10-8-14/h3-10,24-25H,11-12H2,1-2H3

InChi Key: ZKJAZFUFPPSFCO-UHFFFAOYSA-N