Importazole | B2958

Importazole is a 2,4-diaminoquinazoline that inhibits the function of transport receptor importin-β, likely by altering its interaction with RanGTP. Importazole prevents nuclear import of GFP-tagged nuclear factor of activated T cells (NFAT-GFP) in HEK293 cells with an IC₅₀ of 15 μM, which is reversible upon importazole washout. Importazole inhibits nuclear import of topoisomerase IIβ binding protein 1 (TopBP1) in Xenopus egg extracts and NF-κB in multiple myeloma cells. It induces apoptosis and inhibits growth of multiple myeloma cell lines with IC₅₀ values of 4.4 μM and 4.8 μM, respectively. It also induces defects in astral MT dynamics and misoriented spindles.

Importazole is a 2,4-diaminoquinazoline that inhibits the function of transport receptor importin-β, likely by altering its interaction with RanGTP. Importazole prevents nuclear import of GFP-tagged nuclear factor of activated T cells (NFAT-GFP) in HEK293 cells with an IC₅₀ of 15 μM, which is reversible upon importazole washout. Importazole inhibits nuclear import of topoisomerase IIβ binding protein 1 (TopBP1) in Xenopus egg extracts and NF-κB in multiple myeloma cells. It induces apoptosis and inhibits growth of multiple myeloma cell lines with IC₅₀ values of 4.4 μM and 4.8 μM, respectively. It also induces defects in astral MT dynamics and misoriented spindles.

B2958 | Importazole DataSheet

Alternate Name/Synonyms: N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine; IPZ

Appearance: Solid

Formulation:

CAS Number: 662163-81-7

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₀H₂₂N₄

Molecular Weight: 318.42

Cell-Permeable?: True

Purity: >98%

Solubilities: ~30 mg/ml in DMSO and DMF in 0, ~5 mg/ml in in Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of the transport receptor importin-β

MDL Number: MFCD04077630

PubChem CID: 2949965

SMILES: CC(C1=CC=CC=C1)NC2=NC(=NC3=CC=CC=C32)N4CCCC4

InChi: InChI=1S/C20H22N4/c1-15(16-9-3-2-4-10-16)21-19-17-11-5-6-12-18(17)22-20(23-19)24-13-7-8-14-24/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,21,22,23)

InChi Key: HKGJEZIGDHFJFL-UHFFFAOYSA-N