IMR-1 | B1131

IMR-1 (Inhibitor of Mastermind Recruitment-1), is a small molecule inhibitor that disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex on chromatin, thereby attenuating Notch target gene transcription. Additionally, IMR-1 inhibits the growth of Notch-dependent cell lines and significantly abrogates the growth of patient-derived tumor xenografts.

IMR-1 (Inhibitor of Mastermind Recruitment-1), is a small molecule inhibitor that disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex on chromatin, thereby attenuating Notch target gene transcription. Additionally, IMR-1 inhibits the growth of Notch-dependent cell lines and significantly abrogates the growth of patient-derived tumor xenografts.

B1131 | IMR-1 DataSheet

Alternate Name/Synonyms: (E)-Ethyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate; Inhibitor of Mastermind Recruitment-1

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 310456-65-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₅H₁₅NOS₂

Molecular Weight: 353.41

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A small molecule inhibitor of Mastermind Recruitment-1

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(OCC)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC

InChi: InChI=1S/C15H15NO5S2/c1-3-20-13(17)8-21-10-5-4-9(6-11(10)19-2)7-12-14(18)16-15(22)23-12/h4-7H,3,8H2,1-2H3,(H,16,18,22)/b12-7+

InChi Key: QHPJWPQRZMBKTG-KPKJPENVSA-N