INCB-024360 | 9477

INCB-024360 is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor ( IC₅₀ = 10 nM); displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). Exhibits potent in vitro and in vivo immunomodulating and antineoplastic activities

INCB-024360 is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor ( IC₅₀ = 10 nM); displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). Exhibits potent in vitro and in vivo immunomodulating and antineoplastic activities

9477 | INCB-024360 DataSheet

Alternate Name/Synonyms: (E)-N’-(3-bromo-4-fluorophenyl)-N-hydroxy-4-((2-(sulfamoylamino-1,2,5-oxadiazole-3-carboxamide); Epacadostat; INCB24360

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1204669-58-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₁H₁₃BrFN₇O₄S

Molecular Weight: 438.23

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor

MDL Number: N/A

PubChem CID: 44608567

SMILES: C1=CC(=C(C=C1N/C(=C\2/C(=NON2)NCCNS(=O)(=O)N)/N=O)Br)F

InChi: InChI=1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14,22)23/h1-2,5,16-17,19H,3-4H2,(H,15,20)(H2,14,22,23)/b11-9+

InChi Key: YPBKTZBXSBLTDK-PKNBQFBNSA-N