INCB057643 | B2438

INCB057643 is a potent and selective BET inhibitor; displays more effectivity against androgen-dependent (VCaP and LNCaP) than androgen-independent (DU145 and PC3) cells with IC50 of <100 nM and >500 nM, respectively; significantly causes inhibition of tumor growth in mice bearing 22Rv1 tumor xenografts. INCB057643 inhibits proliferation of prostate cancer cell lines.

INCB057643 is a potent and selective BET inhibitor; displays more effectivity against androgen-dependent (VCaP and LNCaP) than androgen-independent (DU145 and PC3) cells with IC50 of <100 nM and >500 nM, respectively; significantly causes inhibition of tumor growth in mice bearing 22Rv1 tumor xenografts. INCB057643 inhibits proliferation of prostate cancer cell lines.

B2438 | INCB057643 DataSheet

Alternate Name/Synonyms:

Appearance: Crystalline solid

Formulation:

CAS Number: 1820889-23-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₁N₃O₅S

Molecular Weight: 415.46

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective BET inhibitor

MDL Number:

PubChem CID: 118467751

SMILES: CC1(C(=O)N(C2=C(O1)C(=CC(=C2)S(=O)(=O)C)C3=CN(C(=O)C4=C3C=CN4)C)C)C

InChi: InChI=1S/C20H21N3O5S/c1-20(2)19(25)23(4)15-9-11(29(5,26)27)8-13(17(15)28-20)14-10-22(3)18(24)16-12(14)6-7-21-16/h6-10,21H,1-5H3

InChi Key: VZSAMEOETVNDQH-UHFFFAOYSA-N