LBD
ING2 Antibody (Center) [APR31831G]
- SKU:
- LBD-APR31831G
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Description
ING2 Antibody (Center) [APR31831G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This ING2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-141 amino acids from the Central region of human ING2.
Cellular Localisation: Nucleus. Note=Predominantly nuclear. Localized to chromatin and nuclear matrix Upon reduced PtdIns (5) P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm
Molecular Weight: 32808
Clone: Polyclonal
Gene Name: ING2
Gene ID: 3622
Function: Seems to be involved in p53/TP53 activation and p53/TP53- dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) .
Summary: Tissue Location: Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Inhibitor of growth protein 2, Inhibitor of growth 1-like protein, ING1Lp, p32, p33ING2, ING2, ING1L