ING2 Antibody (Center) [APR31831G]

ING2 Antibody (Center) [APR31831G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ING2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-141 amino acids from the Central region of human ING2.

Cellular Localisation: Nucleus. Note=Predominantly nuclear. Localized to chromatin and nuclear matrix Upon reduced PtdIns (5) P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm

Molecular Weight: 32808

Clone: Polyclonal

Gene Name: ING2

Gene ID: 3622

Function: Seems to be involved in p53/TP53 activation and p53/TP53- dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) .

Summary: Tissue Location: Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Inhibitor of growth protein 2, Inhibitor of growth 1-like protein, ING1Lp, p32, p33ING2, ING2, ING1L