Cell-permeable. A potent, irreversible inhibitor of poly (ADP-ribose) polymerase-1 (PARP1). Displays strong anti-neoplastic properties.Iniparib is a potent, irreversible inhibitor of poly...
Siremadlin (NVP-HDM201) is a potent and highly specific MDM-2/p53 inhibitor. It binds to human MDM2 protein with a picomolar Ki value (0.21 nM). It activates p53 and induces robust p53-dependent cell...