INPP5D Polyclonal Antibody | E-AB-70200

INPP5D Polyclonal Antibody | E-AB-70200 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Inositol polyphosphate 5 phosphatase of 145kDa, 4, 5-trisphosphate 5-phosphatase 1, hp51CN, Inositol polyphosphate 5 phosphatase 145kDa, Inositol polyphosphate 5 phosphatase, Inositol polyphosphate-5-phosphatase of 145 kDa, INPP5D, MGC104855, MGC142140, MGC142142, p150Ship, Phosphatidylinositol 3, 4, 5 trisphosphate 5 phosphatase 1, Phosphatidylinositol-3, SH2 containing inositol phosphatase isoform b, SH2 domain containing inositol 5' phosphatase 1, SH2 domain containing inositol phosphatase 1, SH2 domain-containing inositol phosphatase 1, SH2 domain-containing inositol-5''-phosphatase 1, SHIP-1, SHIP1, SHIP1, Signaling inositol polyphosphate 5 phosphatase SIP 145, SIP-145, SIP145

Application: IHC

Reactivity: Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Immunology, Signal Transduction

Background: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3, 4, 5)-trisphosphate and inositol-1, 3, 4, 5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.

Concentration: 430 μg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse SHIP1

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification Method: Affinity purification

Dilution: IHC 1:200-1:1000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A