INSIG2 polyclonal Antibody | BS8060

INSIG2 polyclonal Antibody | BS8060 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200

Background: INSIG-1 and INSIG-2 play distinct roles in a negative-feedback mechanism for cholesterol synthesis. INSIG-1 localizes to the endoplasmic reticulum (ER) and binds the sterol-sensing domain of SREBP cleavage-activating protein (SCAP) . Sterol induces INSIG-1 binding to SCAP. INSIG-2, another ER protein, binds SCAP in a sterol-regulated manner. Thus, INSIG-1 and INSIG-2 block the export of SCAP from the ER and ultimately inhibit cholesterol synthesis by preventing the proteolytic processing of SREBPs by Golgi enzymes. The critical role of INSIG-1 and INSIG-2 in cholesterol metabolism may be exploited as a therapeutic effect for hypercholesterolemia.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: INSIG2 polyclonal Antibody detects endogenous levels of INSIG2 protein.

Molecular Weight: ~ 25 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Insulin-induced gene 2 protein; INSIG-2; INSIG2

Immunogen: Recombinant full length Human INSIG2.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A