Insulin Receptor (phospho-Y1361) polyclonal Antibody | BS4426

Insulin Receptor (phospho-Y1361) polyclonal Antibody | BS4426 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular β subunit and an extracellular α subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-Insulin Receptor (Y1361) pAb detects endogenous levels of Insulin Receptor protein only when phosphorylated at Tyr1361

Molecular Weight: ~ 95, 156 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Insulin receptor; IR; CD220; INSR

Immunogen: Synthetic phosphopeptide derived from human Insulin Receptor around the phosphorylation site of Tyrosine 1361.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A