Integrin alpha 6 Polyclonal Antibody | BS65611

Integrin alpha 6 Polyclonal Antibody | BS65611 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,  (predicted: Mouse, Rat, Chicken, Cow, )

Application: WB,

Application Range: WB=1:500-2000

Background: Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Integrin alpha 6 complexes are receptors for laminins, which are components of basement membranes. Integrin alpha 6 complexes may play an important role in embryogenesis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Integrin alpha 6 Polyclonal Antibody detects endogenous levels of Integrin alpha 6 protein.

Molecular Weight: 115 kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Integrin alpha-6; Alpha6p; VLA 6 alpha subunit; VLA 6; VLA-6; Integrin α6; CD49 antigen-like family member F; CD49f; Integrin alpha6B; Integrin, alpha 6; ITA6_HUMAN; ITGA6; ITGA6B; Processed integrin alpha-6.

Immunogen: KLH conjugated synthetic peptide derived from human Integrin alpha 6:1031-1130/1130

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: