IOX1 | 2266

Cell-permeable. A histone demethylase (HDM) JMJD nhibitor. Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC₅₀s = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 µM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively. A broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling.

IOX1 is a histone demethylase (HDM) JMJD nhibitor. Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC₅₀s = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 µM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively.

2266 | IOX1 DataSheet

Alternate Name/Synonyms: 8-Hydroxy-5-quinolinecarboxylic acid; 8-Hydroxy-5-quinolinecarboxylic acid

Appearance: Yellow solid

Formulation: N/A

CAS Number: 5852-78-8

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₁₀H₇NO₃

Molecular Weight: 189.17

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: Histone demethylase JMJD inhibitor

MDL Number: MFCD18417145

PubChem CID: 459617

SMILES: C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O

InChi: InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)

InChi Key: JGRPKOGHYBAVMW-UHFFFAOYSA-N