IOX3 (FG-2216) | B2739

IOX3 (FG-2216) is a potent, orally bioavailable HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.9 µM for PDH2 enzyme. It has been shown to reversibly stimulate erythropoietin secretion at 100 µM in vitro.

IOX3 (FG-2216) is a potent, orally bioavailable HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.9 µM for PDH2 enzyme. It has been shown to reversibly stimulate erythropoietin secretion at 100 µM in vitro.

B2739 | IOX3 (FG-2216) DataSheet

Alternate Name/Synonyms: N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-glycine

Appearance: Crystalline solid

Formulation:

CAS Number: 223387-75-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₉ClN₂O₄

Molecular Weight: 280.7

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~20 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An orally active PHD2 inhibitor

MDL Number:

PubChem CID: 6914666

SMILES: OC1=C(C(NCC(O)=O)=O)N=C(Cl)C2=CC=CC=C21

InChi: InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17)

InChi Key: OUQVKRKGTAUJQA-UHFFFAOYSA-N