IPA-3 | 2647

IPA-3 is a cell-permeable allosteric inhibitor of PAK1 (tha p21-activated kinase 1) that is non-competitive with respect to ATP binding (IC₅₀ = 2.5 µM). It does not, however, inhibit the activity of PAK1 that has been pre-activated with Cdc42. IPA-3 binds covalently to the PAK1 regulatory domain (apparent Kd = 1.9 uM) and prevents binding to the upstream activator Cdc42. Potential anti-tumor agent.

IPA-3 is a cell-permeable allosteric inhibitor of PAK1 (tha p21-activated kinase 1) that is non-competitive with respect to ATP binding (IC₅₀ = 2.5 µM). It does not, however, inhibit the activity of PAK1 that has been pre-activated with Cdc42. IPA-3 binds covalently to the PAK1 regulatory domain (apparent Kd = 1.9 uM) and prevents binding to the upstream activator Cdc42. Potential anti-tumor agent.

2647 | IPA-3 DataSheet

Alternate Name/Synonyms: 1,​1'-​dithiobis-​2-​naphthalenol

Appearance: Yellow solid

Formulation: N/A

CAS Number: 42521-82-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₄O₂S₂

Molecular Weight: 350.45

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO (~ 25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A PAK1 inhibitor

MDL Number: MFCD00388917

PubChem CID: 521106

SMILES: C1=CC=C2C(=C1)C=CC(=C2SSC3=C(C=CC4=CC=CC=C43)O)O

InChi: InChI=1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H

InChi Key: RFAXLXKIAKIUDT-UHFFFAOYSA-N