XMD8-87 | B2647

XMD8-87 is a potent Ack1/TNK2 inhibitor (IC₅₀ = 38 and 113 nM in Ba/F3 cell lines containing leukemia-associated D163E and R806Q mutations respectively). XMD8-87 potently inhibits phosphorylation of TNK2 truncation mutations found in solid tumor types.

XMD8-87 is a potent Ack1/TNK2 inhibitor (IC₅₀ = 38 and 113 nM in Ba/F3 cell lines containing leukemia-associated D163E and R806Q mutations respectively). XMD8-87 potently inhibits phosphorylation of TNK2 truncation mutations found in solid tumor types.

B2647 | XMD8-87 DataSheet

Alternate Name/Synonyms: 5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

Appearance: Off-white solid

Formulation:

CAS Number: 1234480-46-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₇N₇O₂

Molecular Weight: 445.5

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >20 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent Ack1/TNK2 inhibitor

MDL Number:

PubChem CID: 53322923

SMILES: CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C5=CC=CC=C5C(=O)N4)C)OC

InChi: InChI=1S/C24H27N7O2/c1-29-10-12-31(13-11-29)16-8-9-18(21(14-16)33-3)27-24-25-15-19-22(28-24)30(2)20-7-5-4-6-17(20)23(32)26-19/h4-9,14-15H,10-13H2,1-3H3,(H,26,32)(H,25,27,28)

InChi Key: LGLHCXISMKHLIK-UHFFFAOYSA-N