IPI-145 | 2445

PI-145 is a potent inhibitor of phosphoinositide-3-kinase (PI3K)-d and PI3K-γ isoforms with potential immunomodulating and antineoplastic activities. IPI-145 prevents the activation of the PI3Kd/γ-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3Kd/γ-expressing tumor cells.

IPI-145 is a potent inhibitor of phosphoinositide-3-kinase (PI3K)-d and PI3K-γ isoforms with potential immunomodulating and antineoplastic activities.

2445 | IPI-145 DataSheet

Alternate Name/Synonyms: (S)-3-(1-((9H-purin-6-yl)amino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one

Appearance: White solid

Formulation: N/A

CAS Number: 1201438-56-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₁₇ClN₆O

Molecular Weight: 416.86

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent PI3K-delta/gamma isoform inhibitor

MDL Number: N/A

PubChem CID: 50905713

SMILES: CC(C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

InChi: InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1

InChi Key: SJVQHLPISAIATJ-ZDUSSCGKSA-N