IPI-549 | B1971

IPI-549 is a potent and selective PI3Kγ Inhibitor (IC₅₀ of 16 nM). It displays no significant inhibition for a panel of 468 mutant and non-mutant protein and lipid kinases (including Class II PI3K isoforms) at 1 µM.

IPI-549 is a potent and selective PI3Kγ Inhibitor (IC₅₀ of 16 nM). It displays no significant inhibition for a panel of 468 mutant and non-mutant protein and lipid kinases (including Class II PI3K isoforms) at 1 µM.

B1971 | IPI-549 DataSheet

Alternate Name/Synonyms: 2-amino-N-[1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1693758-51-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₂₄N₈O₂

Molecular Weight: 528.56

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective PI3Kγ Inhibitor

MDL Number: N/A

PubChem CID: 118004470

SMILES: CC(C1=CC2=CC=CC(=C2C(=O)N1C3=CC=CC=C3)C#CC4=CN(N=C4)C)NC(=O)C5=C6N=CC=CN6N=C5N

InChi: InChI=1S/C30H24N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6-8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3-11,14-19H,1-2H3,(H2,31,35)(H,34,39)

InChi Key: XUMALORDVCFWKV-UHFFFAOYSA-N