IPMK Antibody (Center) [APR16880G]

IPMK Antibody (Center) [APR16880G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This IPMK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-329 amino acids from the Central region of human IPMK.

Cellular Localisation: Nucleus.

Molecular Weight: 47222

Clone: Polyclonal

Gene Name: IPMK

Gene ID: 253430

Function: Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931) . Phosphorylates inositol 1, 4, 5-trisphosphate (Ins (1, 4, 5) P3) first to inositol 1, 3, 4, 5-tetrakisphosphate and then to inositol 1, 3, 4, 5, 6-pentakisphosphate (Ins (1, 3, 4, 5, 6) P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931) . Phosphorylates inositol 1, 3, 4, 6-tetrakisphosphate (Ins (1, 3, 4, 6) P4) (PubMed:12223481) . Phosphorylates glycero-3-phospho-1D-myo-inositol 4, 5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3, 4, 5- trisphosphate (PubMed:30420721, PubMed:28882892) . Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) . Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho- MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610) . Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1, 3, 4, 5, 6-pentakisphosphate (Ins (1, 3, 4, 5, 6) P5) and inositol hexakisphosphate (InsP6) (By similarity) .

Summary: Tissue Location: Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Inositol polyphosphate multikinase, Inositol 1, 6-tetrakisphosphate 5-kinase, IPMK, IMPK