IQ-1 | 1663

Maintains the undifferentiated state of embryonic stem cells. By targeting the PR72/130 subunit of the Ser/Thr phosphatase PP2A, it prevents β-catenin from switching coactivator usage from CBP to p300. The increase in β-cateinin/CBP mediated transcription at the expense of β-cateinin/p300-mediated transcription helps to maintain the murine stem cell pluripotency.

IQ-1 maintains the undifferentiated state of embryonic stem cells. By targeting the PR72/130 subunit of the Ser/Thr phosphatase PP2A, it prevents β-catenin from switching coactivator usage from CBP to p300.

1663 | IQ-1 DataSheet

Alternate Name/Synonyms: 2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide

Appearance: Orange solid

Formulation: N/A

CAS Number: 331001-62-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₂N₄O₂

Molecular Weight: 362.42

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A stem cell differentiating agent

MDL Number: MFCD00354369

PubChem CID: 11152734

SMILES: CC(=O)C1=CC=C(C=C1)N=NC(C2C3=CC=CC=C3CC(N2)(C)C)C(=O)N

InChi: InChI=1S/C21H24N4O2/c1-13(26)14-8-10-16(11-9-14)24-25-19(20(22)27)18-17- 7-5-4-6-15(17)12-21(2,3)23-18/h4-11,18-19,23H,12H2,1-3H3,(H2,22,27)

InChi Key: WQFHCZGUBRVAAW-UHFFFAOYSA-N