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IQGAP1 polyclonal Antibody | BS90734
- SKU:
- BW-BS90734
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- Usually ships in 5 working days
Description
IQGAP1 polyclonal Antibody | BS90734 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse
Application: WB ICC IF IHC FC
Application Range: WB:1:500-1:2,000 ICC/IF:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: IQGAP1, for IQ motif containing GTPase activating protein, is a Ras GAP-related, Actin-binding protein that interacts with the small GTPases Cdc42 and Rac1. The C-terminus of IQGAP1 is essential for interacting with Cdc42 and, in addition, IQGAP1 contains a WW domain and a predicted N-terminal coiled-coil region, which may be involved in IQGAP dimerization. Expression of IQGAP1 is highest in placenta, lung and kidney, where it co-localizes with Cdc42 to the cytoskeleton and assists with Cdc42 in mediating the regulation of cell proliferation, polarity and cell morphology. IQGAP1 regulates cadherin-mediated cell adhesion via binding to E-cadherin, b-catenin and a-catenin. This association induces the accumulation of these proteins at the site of cell-cell contact. IQGAP1 is negatively regulated by calmodulin, which binds to IQGAP1 in a calcium-dependent manner and disrupts IQGAP1 from associating with Cdc42.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: IQGAP1 polyclonal Antibody detects endogenous levels of IQGAP1 protein.
Molecular Weight: 189 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: IQGAP1, KIAA0051, HUMORFA01, IQ motif containing GTPase activating protein 1, IQGA1, Iqgap1, KIAA0051, p195, Ras GTPase activating like protein 1, Ras GTPase-activating-like protein IQGAP1, RasGAP-like with IQ motifs, SAR1,
Immunogen: Recombinant protein corresponding to N-terminal human IQGAP1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: Toll-like Receptor signaling,