IRAK3 Antibody (N-term) [APR32500G]

IRAK3 Antibody (N-term) [APR32500G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This IRAK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-77 amino acids from the N-terminal region of human IRAK3.

Cellular Localisation: Cytoplasm. Nucleus. Note=In dendritic cells, translocates into the nucleus upon IL33 stimulation. {ECO:0000250|UniProtKB:Q8K4B2}

Molecular Weight: 67767

Clone: Polyclonal

Gene Name: IRAK3 {ECO:0000312|EMBL:AAH57800.1}

Gene ID: 11213

Function: Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383) . Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity) . Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383) .

Summary: Tissue Location: Expressed in eosinophils, dendritic cells and/or monocytes (at protein level) (PubMed:29686383) . Expressed predominantly in peripheral blood lymphocytes (PubMed:10383454)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: IHC-P--1:100 WB--1:500

Synonyms: Interleukin-1 receptor-associated kinase 3, IRAK-3, IL-1 receptor-associated kinase M, IRAK-M, IRAK3 {ECO:0000312|EMBL:AAH578001}