IRF2 Antibody (Center) [APR03541G]

IRF2 Antibody (Center) [APR03541G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This IRF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-255 amino acids from the Central region of human IRF2.

Cellular Localisation: Nucleus.

Molecular Weight: 39354

Clone: Polyclonal

Gene Name: IRF2

Gene ID: 3660

Function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS) ) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.

Summary: Tissue Location: Expressed throughout the epithelium of the colon. Also expressed in lamina propria.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Interferon regulatory factor 2, IRF-2, IRF2