Irinotecan Hydrochloride | 1752

An anticancer agent. This is a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I.

Irinotecan Hydrochloride is an an anticancer agent. This is a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I.

1752 | Irinotecan Hydrochloride DataSheet

Alternate Name/Synonyms: S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo1H-pyrano[3’,4’:6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4’bipiperidine]-1’-carboxylate, Hydrochloride

Appearance: Yellow solid

Formulation: N/A

CAS Number: 100286-90-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₃H₃₈N₄O₆. HCl

Molecular Weight: 623.14

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (50 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A DNA topoisomerase I inhibitor

MDL Number: MFCD01862255

PubChem CID: 74990

SMILES: CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7.Cl

InChi: InChI=1S/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2, 1-2H3;1H/t33-;/m0./s1

InChi Key: GURKHSYORGJETM-WAQYZQTGSA-N