Iron Chelator, Dp44MT | 9634

Dp44MT is a cell-permeable iron chelator. This di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand displays potent and selective antiproliferative properties in neoplastic cells and minimally affects normal cells. Dp44mT prevents aggressive growth of M109 lung carcinoma in mice and has been shown to mobilize cellular iron effectively, and generate ROS leading to apoptosis.

Dp44MT is a cell-permeable iron chelator. This di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand displays potent and selective antiproliferative properties in neoplastic cells and minimally affects normal cells. Dp44mT prevents aggressive growth of M109 lung carcinoma in mice and has been shown to mobilize cellular iron effectively, and generate ROS leading to apoptosis.

9634 | Iron Chelator, Dp44MT DataSheet

Alternate Name/Synonyms: 2-(Di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide, Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone

Appearance: Yellow to orange solid

Formulation: N/A

CAS Number: 152095-12-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₁₅N₅S

Molecular Weight: 285.37

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A cell-permeable iron chelator

MDL Number: MFCD20527329

PubChem CID: 10334137

SMILES: CN(C)C(=S)NN=C(C1=CC=CC=N1)C2=CC=CC=N2

InChi: InChI=1S/C14H15N5S/c1-19(2)14(20)18-17-13(11-7-3-5-9-15-11)12-8-4-6-10-16-12/h3-10H,1-2H3,(H,18,20)

InChi Key: XOBIGRNRXCAMJQ-UHFFFAOYSA-N