ISCK03 | B2274

ISCK03 is a cell-permeable Stem-Cell Factor/c-Kit Inhibitor that inhibits c-kit activity (IC₅₀ <2.5 μM in cell-free kinase assays) and blocks SCF-induced c-kit and Erk phosphorylation (1 μM causes >90% inhibition) without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells.

ISCK03 is a cell-permeable Stem-Cell Factor/c-Kit Inhibitor that inhibits c-kit activity (IC₅₀ <2.5 μM in cell-free kinase assays) and blocks SCF-induced c-kit and Erk phosphorylation (1 μM causes >90% inhibition) without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells.

B2274 | ISCK03 DataSheet

Alternate Name/Synonyms: 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-benzenesulfonamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 945526-43-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₁N₃O₂S

Molecular Weight: 355.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A cell-permeable Stem-Cell Factor/c-Kit Inhibitor

MDL Number: MFCD12031591

PubChem CID: 3792751

SMILES: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3

InChi: InChI=1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3

InChi Key: ABBHBFHWHMKF-UHFFFAOYSA-N